Ozone and lung remodeling
More than 4 in 10 US people live in areas with unhealthy levels of ozone. The San Joaquin Valley (SJV) is a hot spot of high ozone exposures. Four of the top 7 most ozone polluted cities in the US are in the SJV where ozone affects more than 1 million children. Ozone exposure during childhood alters lung growth â even healthy young adults from high ozone environments have decreased lung function â yet the mechanisms are little understood. Much research hasÂ focused on ozone exacerbation of asthma. Dr.
Immune mechanisms of ozone-induced lung inflammation in non-human primates
PersistentÂ exposure to air pollution leads to changes in immune function inÂ the respiratory system. These changesÂ canÂ trigger allergic asthmaÂ and increase susceptibility to respiratory infections. Exposure to high levels of ozone, a major toxic air pollutant, worsens asthma and COPD symptoms. While the exact mechanisms of ozone induced airway diseaseÂ are not understood, Dr.
Postnatal Neuroimmune Integration of Environmental Stresses
Over the last 40 years, epidemiological studies have shown a disturbing trend of increasing incidence of allergic asthma in children. A wide range of stressors in the womb or during early life can increase the risk of developing allergic childhood asthma.