respiratory disease

Laura Van Winkle, PhD - Department of Anatomy, Physiology and Cell Biology

May 16, 2017
Ozone and lung remodeling More than 4 in 10 US people live in areas with unhealthy levels of ozone. The San Joaquin Valley (SJV) is a hot spot of high ozone exposures. Four of the top 7 most ozone polluted cities in the US are in the SJV where ozone affects more than 1 million children. Ozone exposure during childhood alters lung growth – even healthy young adults from high ozone environments have decreased lung function – yet the mechanisms are little understood. Much research has focused on ozone exacerbation of asthma. Dr.

Angela Haczku, MD, PhD - Department of Internal Medicine

May 16, 2017
Immune mechanisms of ozone-induced lung inflammation in non-human primates Persistent exposure to air pollution leads to changes in immune function in the respiratory system. These changes can trigger allergic asthma and increase susceptibility to respiratory infections. Exposure to high levels of ozone, a major toxic air pollutant, worsens asthma and COPD symptoms. While the exact mechanisms of ozone induced airway disease are not understood, Dr.