Role of Environmental Chemicals in the Pathogenesis of Autoimmune Disease
Although it is well known that environmental pollution poses significant health hazards, data on the environment and human autoimmunity are limited.
Dysregulation of MicroRNAs in Ocular Tissue Exposed to Cigarette Smoke
Age-related macular degeneration (AMD), a blinding disease having both genetic and environmental components, is the most common form of visual impairment in elderly individuals of the Western world, and smoking is the leading identified associated environmental insult. Recently, a central regulatory role for a novel type of molecule, microRNA (miRNA), had been discovered in many human diseases.
Maternal Metabolome, PON1 Status, Organophosphate Exposure and Childhood Autism
With the rapid rise in autism spectrum disorder (ASD) diagnoses over the last three decades, identification of the causes and mechanisms of this condition is urgently needed. Building on recent findings that children prenatally exposed to pesticides have an increased risk of an ASD diagnosis, serum from children was previously analyzed. A distinct metabolic pattern was found in children with ASD who were exposed to pesticides in utero that revealed associations with insulin regulation.
Postnatal Neuroimmune Integration of Environmental Stresses
Over the last 40 years, epidemiological studies have shown a disturbing trend of increasing incidence of allergic asthma in children. A wide range of stressors in the womb or during early life can increase the risk of developing allergic childhood asthma.
Environmental Oxidants and the Aging Male: Sperm Function and Embryo Development
Age-dependent accumulation of testicular oxidative insult very likely leads to declining sperm function and fertility, cellular damage to spermatogenic stem cells, inefficiency of sperm production, inefficient mitochondrial metabolism, and mutations in nuclear and mitochondrial DNA.
Gastrointestinal Pathophysiology Following Early Life Environmental Exposure
The microbiota-gut-brain axis (MGB axis) is an important pathway for maintaining health and well-being. Disruptions in the axis have been identified in numerous disease states, including inflammatory bowel disease, diabetes and autism spectrum disorder. Early development is an important life stage for normal establishment of the microbiota, development of the gastrointestinal (GI) tract and neurobiological growth and maturation, which together modulate the MGB axis.
Facilitating Real-Time Exposure Studies on Traffic Related Air Pollution
Toxicological studies continue to demonstrate causal relationship between exposures to traffic related air pollution (TRAP), including gases and particles, and various metrics of adverse pulmonary, cardiovascular and neurological health effects.
The key challenge in these studies is replicating true human exposure in models that mimic human biology on accelerated time scales with sufficient resolution in physiological and/or behavioral response to demonstrate statistical significance.