Behavioral and neuroimaging phenotypes following early life pesticide exposure
Worldwide, organophosphate pesticides are the most commonly used class of pesticides. Epidemiological studies have linkedÂ their use to autism, attention deficit hyperactivity disorder, developmental delay, and other neurodevelopmental disorders. Currently, the impactsÂ of early-life exposure to low doses that are representative ofÂ what people and,Â in particular, pregnant women and children may experience, have not been well-studied. Dr.
Maternal Metabolome, PON1 Status, Organophosphate Exposure and Childhood Autism
With the rapid rise in autism spectrum disorder (ASD) diagnoses over the last three decades, identification of the causes and mechanisms of this condition is urgently needed. Building on recent findings that children prenatally exposed to pesticides have an increased risk of an ASD diagnosis, serum from children was previously analyzed. A distinct metabolic pattern was found in children with ASD who were exposed to pesticides in utero that revealed associations with insulin regulation.