Dr. Lillian Cruz-Orengo is an Assistant Professor of Anatomy, Physiology & Cell Biology at the School of Veterinary Medicine. Her research focuses on the neuro-immune interactions at the blood-brain barrier (BBB) as a relevant contributor to neuropathogenesis and neuroinflammation, toward finding non-immunosuppressive therapeutic targets.

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Positions at UC Davis

• Assistant Professor, School of Veterinary Medicine
• Neuroimmunology Lab

Areas of Expertise

• Neuroimmunology
• Neuroinflammation
• Brain Barriers
• Molecular Neuroscience
• Autoimmunity

Major Research Papers

Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Front Cell Neurosci. 2021; 15:683687. Dayton JR, Yuan Y, Pacumio LP, Dorflinger BG, Yoo SC, Olson MJ, Hernández-Suárez SI, McMahon MM, Cruz-Orengo L. PMID: 34557075; PMCID: PMC8452993.

Strain and sex differences in somatosensation and sociability during experimental autoimmune encephalomyelitis. Brain Behav Immun Health. 2021 Jul; 14:100262. Ondek K, Nasirishargh A, Dayton JR, Nuño MA, Cruz-Orengo L. PMID: 34589768; PMCID: PMC8474462.

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups. J Vis Exp. 2020 01 12; (155). Yuan Y, Dayton JR, Freese ML, Dorflinger BG, Cruz-Orengo L. PMID: 31984956.

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse. J Vis Exp. 2019 08 15; (150). Brien JD, Hassert M, Stone ET, Geerling E, Cruz-Orengo L, Pinto AK. PMID: 31475971.

Straightforward method for singularized and region-specific CNS microvessels isolation. J Neurosci Methods. 2019 04 15; 318:17-33. Dayton JR, Franke MC, Yuan Y, Cruz-Orengo L. PMID: 30797797