Jill Silverman

Member, Environmental Health Sciences Center

Dr. Jill Silverman is a Professor in the Department of Psychiatry and Behavioral Sciences. Her research at the Silverman Lab involves rodent model systems to design and implement effective translational science for neurodevelopmental disorders. The lab focuses on preclinical research in multiple species to characterize and treat rare neurodevelopment disorders.

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Positions at UC Davis

  • PI, Silverman lab
  • Professor, Department of Psychiatry and Behavioral Sciences

Areas of Expertise

  • Neurodevelopmental Disorders
  • Behavioral Neuroscience
  • Genetics

Major Research Papers

Berg EL, Petkova SP, Born HA, Adhikari A, Anderson AE, Silverman JL. Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome. Mol Autism. 2021 Sep 15;12(1):59. doi:10.1186/s13229-021-00467-1. PMID:34526125.

Berg EL, Shekib AJ, Petkova SP, Ellegood J, Fenton TA, Segal DJ, Gray JA, Wöhr M, Silverman JL. Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Ube3a Deletion Rat Model of Angelman Syndrome. J Neuroscience. 2021 Sep 2:JN-RM-0925-21. doi:10.1523/JNEUROSCI.0925-21.2021. PMID:34475199.

Copping NA, McTighe SM, Fink KD, Silverman JL. Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome. Neurotherapeutics. 2021 Jul;18(3):1535-1547. doi:10.1007/s13311-021-01082-x. Epub 2021 Sep 15. PMID:34528170.

Adhikari A, Copping NA, Beegle J, Cameron DL, Deng P, O'Geen H, Segal DJ, Fink KD, Silverman JL, Anderson JS. Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells. Hum Mol Genet. 2021 Jun 9;30(12):1067-1083. doi:10.1093/hmg/ddab104. PMID:33856035.

Haigh JL, Adhikari A, Copping NA, Stradleigh T, Wade AA, Catta-Preta R, Su-Feher L, Zdilar I, Morse S, Fenton TA, Nguyen A, Quintero D, Agezew S, Sramek M, Kreun EJ, Carter J, Gompers A, Lambert JT, Canales CP, Pennacchio LA, Visel A, Dickel DE, Silverman JL, Nord AS. Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice. Genome Med. 2021 Apr 26;13(1):69. doi:10.1186/s13073-021-00884-0. PMID:33910599

Education and Degree(s)
  • B.A. Biology and Psychology Honors: Psychology, 1999
  • Ph. D. Neuroscience, University of Maryland, 2007
  • MD Postdoctoral Training, Behaviorual Pharamacology and Genetics, National Institute of Mental Health Laboratory of Behavioral Neuroscience, 2010
Honors and Awards
  • California Institute for Regenerative Medicine (CIRM), DISC2 AAV9-Cas13 gene therapy for Angelman syndrome Role: co-I Segal PI (Segal),
  • RDM POSITIVE IMPACT FOUNDATION $1,250,000 05/01/2021-04/30/2024 Targeted Therapeutic Development Program for SYNGAP1-related Intellectual Disability Role: PI,
  • Foundation for Angelman Syndrome for Therapeutics (FAST) 01/01/2020-12/31/2025 $2,976,004 FAST Research Infrastructure Grant: Training the Next Generation of Angelman Syndrome Scientists Role: co-PI (Silverman, Segal),
  • NIH/NINDS 1R01NS097808-01A1$1,715,000 4/15/2017-1/31/2022 Phenotypic Characterization of Novel Models of Dup15q Syndrome Role: PI,
  • National Institute of Child Health and Human Development, MIND Institute Center for Excellence for Intellectual Disabilities, IDDRC, P50HD103526, (PI Abbeduto) 10/1/2013-5/31/2025 $1,300,000 Co-Investigator Jill L Silverman, Co-Director, Rodent Behavioral