Environmental Health Sciences Center

Dr. Gino Cortopassi is a professor of Molecular Biosciences at the UC Davis School of Veterinary Medicine. The Cortopassi Lab designs new drugs to hit novel drug targets, including ameliorating diabetes & liver disease, neurodegenerative disease, and cancer

Positions At UC Davis

• Professor, Molecular Biosciences, School of Veterinary Medicine
• Principal Investigator, Cortopassi Lab

Areas of Expertise

• Pharmacology & drug design
• Mitochondria and Shc and mTOR as drug targets to ameliorate disease

Major Research Papers

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern. Environ Sci Technol. 2023 05 23; 57(20):7645-7665. Arnold WA, Blum A, Branyan J, Bruton TA, Carignan CC, Cortopassi G, Datta S, DeWitt J, Doherty AC, Halden RU, Harari H, Hartmann EM, Hrubec TC, Iyer S, Kwiatkowski CF, LaPier J, Li D, Li L, Muñiz Ortiz JG, Salamova A, Schettler T, Seguin RP, Soehl A, Sutton R, Xu L, Zheng G. PMID: 37157132; PMCID: PMC10210541.

Androgen receptor-dependent regulation of metabolism in high grade bladder cancer cells. Sci Rep. 2023 01 31; 13(1):1762. Katleba KD, Tsamouri MM, Jathal M, Baek HB, Armenta RB, Tepper CG, Cortopassi G, Ghosh PM, Mudryj M. PMID: 36720985; PMCID: PMC9889754.

Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis. Cell Mol Gastroenterol Hepatol. 2023; 15(1):197-211. Li Y, Jiang JX, Fan W, Fish SR, Das S, Gupta P, Mozes G, Vancza L, Sarkar S, Kunimoto K, Chen D, Park H, Clemens D, Tomilov A, Cortopassi G, Török NJ. PMID: 36122677; PMCID: PMC9676381

A Drug Combination Rescues Frataxin-Dependent Neural and Cardiac Pathophysiology in FA Models. Front Mol Biosci. 2022; 9:830650. Abeti R, Jasoliya M, Al-Mahdawi S, Pook M, Gonzalez-Robles C, Hui CK, Cortopassi G, Giunti P. PMID: 35664670; PMCID: PMC9160322.

The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer's Disease PSAPP Mouse Model. Epigenomes. 2021 Nov 25; 5(4). Casciaro F, Persico G, Rusin M, Amatori S, Montgomery C, Rutkowsky JR, Ramsey JJ, Cortopassi G, Fanelli M, Giorgio M. PMID: 34968250; PMCID: PMC8715457.