Ozone and lung remodeling
More than 4 in 10 US people live in areas with unhealthy levels of ozone. The San Joaquin Valley (SJV) is a hot spot of high ozone exposures. Four of the top 7 most ozone polluted cities in the US are in the SJV where ozone affects more than 1 million children. Ozone exposure during childhood alters lung growth â even healthy young adults from high ozone environments have decreased lung function â yet the mechanisms are little understood. Much research hasÂ focused on ozone exacerbation of asthma. Dr.
Behavioral and neuroimaging phenotypes following early life pesticide exposure
Worldwide, organophosphate pesticides are the most commonly used class of pesticides. Epidemiological studies have linkedÂ their use to autism, attention deficit hyperactivity disorder, developmental delay, and other neurodevelopmental disorders. Currently, the impactsÂ of early-life exposure to low doses that are representative ofÂ what people and,Â in particular, pregnant women and children may experience, have not been well-studied. Dr.
Effects of atrazine on the developing ovary
Atrazine,Â a widely used weed killer is a common contaminant found inÂ drinking water. Atrazine is a member of a family of chemicals called the xenoestrogens that mimic the hormone estrogen and thereby disrupt endocrine function. AnotherÂ xenoestrogen, bisphenol-A (BPA), causesÂ problems in female reproduction. BPAÂ leads to a âgrand-maternal effectâ that increases the likelihood of developmental problemsÂ in grandchildren.
Noninvasive imaging of immune responses induced by environmental pollutants
Exposure to air pollutants and particulate matter (PM) contribute to an increased riskÂ for cardiovascular and pulmonary health problems resulting from chronic inflammation. Dr. Chris Vogel is usingÂ a new method for noninvasive imaging of immune responses, Positron Emission Tomography (PET) and magnetic resonance imaging (MRI). The goal of the project is to identify the specific sites of inflammation following exposure to particulate matter and potentially other types of environmental exposures.
The UC Davis EHS Center Pilot Projects Program is pleased to announce recipients ofÂ the 2017-2018 pilot awards:
Developmental exposure to organophosphorus pesticides to evaluate airway hyperreactivity - Principal Investigator:Â Ana Cristina Grodzki, PhD (Department of Molecular Biosciences)
Immune mechanisms of ozone-induced lung inflammation in non-human primates - Principal Investigator:Â Angela Haczku, MD, PhD (Department of Internal Medicine: Pulmonary and Critical Care Medicine)
Effects of atrazine on the developing ov